ABCB1 C3435T Gene Polymorphism Frequency and Correlation with Clinical Parameters in Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Frequency of Common Abcb1 Gene Variant C3435t Polymorphism in Pakistani Population
Objective: To determine the frequency of the C3435T; a single nucleotide polymorphism of the ABCB1 gene for the first time in Pakistani population and compare it with the data available from other populations. Study Design: A cross-sectional study. Place and Duration of Study: Sampling was carried out at Combined Military Hospital, Rawalpindi from August 2012 to May 2013 and institute of Biomed...
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Background: Since in multiple sclerosis (MS), changes in speech and voice quality often precede other signs and symptoms; early diagnosis of these changes is necessary. In this study, an acoustic examination of phonation subsystem was performed. Due to the progressive nature of multiple sclerosis, the aim of this study was to examine the correlation between acoustic parameters ...
متن کاملABCB1 (MDR1, P-Glycoprotein) C3435T Gene Polymorphism and its Possible Association with Chronic Myeloid Leukemia Prognosis
Adenosine triphosphate-binding cassette B1 (MDR1multiple drug resistance gene1), a drug transporter gene encodes a transmembrane glycoprotein (P-gp), which functions as an efflux pump for various structurally unrelated anticancer agents and toxins. Our main objective is to study MDR1 gene polymorphism at C3435T in chronic myeloid leukemia (CML) to understand its association with development and...
متن کاملABCB1 Gene C3435T Polymorphism and Drug Resistance in Epilepsy: Evidence Based on 8604 Subjects
BACKGROUND The present study aimed to assess the role of C3435T polymorphism in drug-resistance in epilepsy by a meta-analysis. MATERIAL AND METHODS Databases were obtained from the Cochrane Library, MEDLINE, EMBASE, PubMed, Science Direct database, CNKI, and Wanfang up to October 2014. All the case-control association studies evaluating the role of ABCB1 C3435T in pharmacoresistance to anti-...
متن کاملAssociation of Alu Insertion Polymorphism in Progesterone Receptor Gene with Risk of Multiple Sclerosis
Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...
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ژورنال
عنوان ژورنال: Journal of Neurology & Neurophysiology
سال: 2018
ISSN: 2155-9562
DOI: 10.4172/2155-9562.1000479